Erratum: Targeting the TGFβ signalling pathway in disease

The Role of Wnt Signaling Pathway on the Expression of TGFβ 1 and TGFβ 2 in Cultured Rat Cortical Astrocytes

Introduction: Astrocytes, the most abundant glia in the central nervous system, modulate neuronal survival and function. Astrocytic functions are mediated by synthesis and secretion of wide ranges of polypeptides through mechanism (s) poorly understood. Among these, TGFβs are synthesized and released by the astrocytes. In this study, the involvement of Wnt signaling pathway on the synthesi...

Erratum Signalling to and from the secretory pathway

Introduction Regulation of the secretory pathway by signalling ER export is regulated by signalling Modification of ER chaperones Modulation of COPII recruitment Lipid modification Signalling regulates the functional organisation of the Golgi complex PKD and PtdIns(4)P p38 PKA Signalling during directional cell migration Signalling from the secretory pathway A role for the ER in the compartment...

Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGFβ signalling pathway, both via ERK and the Smad-dependent...

SnapShot: The TGFβ Pathway Interactome

p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...